In 2017, the International Conference on Trustworthy Systems and Their Applications (TSA) and the International Symposium on Dependable Computing and Internet of Things (DCIT) were merged into one large conference and renamed the International Conference on Dependable Systems and Their Applications (DSA). This year will be the ninth meeting after the merge. In the past, both TSA and DCIT were technically sponsored by the IEEE Reliability Society. Following the same tradition, DSA 2025 also has the same technical sponsorship from IEEE. The focus is on innovative methodologies, techniques, tools, and management to produce dependable and trustworthy systems and their applications more cost-effectively. In particular, this year's conference emphasizes using emerging AI and machine learning/deep learning technologies to further enhance existing approaches. DSA 2025 provides an opportunity for academic researchers, industry practitioners, and government policy and decision-makers to exchange ideas and results, share experiences, and explore possible solutions to overcome current challenges. It will be held from November 24-26 and hosted by the American University of Sharjah, which is about 20 minutes from Dubai, the United Arab Emirates.